Amino Acid Is Key to HIV Immune

stanford.edu

At some stages of HIV infection will not progress to AIDS, because of certain amino acids in the body that can destroy cells that have been infected with HIV. This was disclosed by Bruce Walker, an immunology and Director Ragon Institute of the Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University in Charlestown.

According to the invention there is an opportunity to stage of HIV infection may not develop into AIDS and happens to 1 in 300 people. The study begins when Bruce Walker knows the clinical benefits have been owned by several patients who have immunity to HIV through the HIV Controllers Study. Then Bruce Walker and his team took until the DNA from 900 patients with HIV-Controller or with people who have immunity to HIV. Then they compare it with the existing genetic code in which 2,600 gave a normal response to HIV. To compare it: Bruce Walker using Genetic Wide Association Study (GWAS).

Then Genetic Wide Association Study will analyze single nucleotide polymorphism that appears on variations of a particular individual. Furthermore, the study found 300 locations were statistically associated with immunity against HIV. The locations are known to be associated with the genetic coding for immune proteins, hereinafter referred to HLA proteins. Then by using a more detailed mapping of the HLA region, Bruce Walker has found the presence of amino acids on HLA-B proteins are very different between normal individuals and HIV Controller. Bruce Walker says that these amino acids which may be responsible for immunity to HIV. There are 3 million nucleotides present in the human genome and Bruce Walker has found the amino acids that can make normal individuals and HIV Controller different.

HLA-B proteins are one type of protein in charge of fighting the virus, but so far not yet known the mechanism of protein to build immunity against HIV. The understanding of the mechanism of action of these proteins will be the basis for vaccine development. It takes a long time to understand. But the good news is there is knowledge about the immune system.